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自分泌游动因子与其受体系统的肿瘤生物学意义

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摘要 自分泌游动因子(autocrine motility factor,AMF)由肿瘤细胞表达并自分泌产生,与自分泌游动因子受体(autocrine motility factor receptor,AMFR,gp78)结合,可刺激肿瘤细胞移动。AMF是一个家族,与磷酸己糖异构酶(phosphohexose isomerase,PHI)、神经白细胞素(neuroleukin,NLK)和成熟因子(maturation factor,MF)是同一前体基因的表达产物,它们与AMFR结合后能介导多方面的生物学功能。本文重点介绍有关AMF和AMFR蛋白分子的结构特点及其肿瘤生物学意义的研究进展。
作者 张宇丝
出处 《生理科学进展》 CAS CSCD 北大核心 2009年第4期365-368,共4页 Progress in Physiological Sciences
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参考文献9

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