摘要
目的观察葛根素对酒精中毒后家兔离体小肠平滑肌活动的影响,探讨其解酒机制。方法制备家兔十二指肠离体肠段标本,采用常规离体灌注小肠平滑肌标本活动的实验方法,记录用药前后肠段平滑肌自发收缩性活动变化。结果乙醇使家兔小肠平滑肌收缩活动的幅度、频率明显减小,与乙醇单用相比,葛根素使以上两项指标进一步降低,并呈剂量依赖关系。结论葛根素加强了乙醇对小肠活动的抑制作用,可能并非通过其对小肠作用达到解酒之功效。
Objective To investigate the effects of Puerafin on constractive activity of small intestine smooth muscle of alcoholism rabbit and to explore it＇s alleviating alcoholism mechanisms. Methods The routine experimental method of small intestinal smooth muscle isolated from rabbits was used. We recorded the automatic contracting characteristic and changing law before and after taking drugs. Results Ethanol decreased the amplitude and frequency of smooth muscle. Compared with ethanol, the amplitude and frequency of smooth muscle were reduced by injected into Puerarin in dose-dependent manner. Conclusion Puerarin could enhance the inhibitory effects of ethanol on small intestine smooth muscle, so it cannot alleviate alcoholism by the above effects.
出处
《滨州医学院学报》
2009年第5期338-339,342,共3页
Journal of Binzhou Medical University
基金
滨州医学院科技计划(BY2007KJ02)
滨州医学院大学生科技创新活动基金(BY2007DKCX19)
关键词
葛根素
乙醇
小肠平滑肌
Duerarin. alcohol.small intestine smooth muscle
