摘要
目的评价牡蛎壳材料填充兔骨缺损的生物相容性、降解性及成骨能力。方法将牡蛎壳用机械方法碾碎致牡蛎壳粉末。建立牡蛎壳材料修复兔股骨下段骨缺损动物模型。应用组织学、影像学、大体观察研究该材料的生物相容性、降解能力及成骨能力。结果术后组织无明显排斥反应,8周牡蛎壳材料开始降解,16周材料基本降解,24周材料完全降解。结论牡蛎壳材料具有良好的生物相容性,在体内可以发生生物降解,能促进骨修复,成骨方式为传导成骨,呈内向性。
Objective To evaluate the biocompatibility,degradation and ossification of oyster shell in bone defect of rabbits. Methods Crush oyster shell to powders by machine and implant them in distal bone defects of femur of adult rabbits. The biocompatibility ,degradation and ossification of oyster shell was evaluated by means of X-ray and histomorphological analysis. Results There were not any rejection in all rabbits. The degradation of oyster shell began at 8 weeks after operation,general done at 16 weeks and completed at 24 weeks after operation. Conclusion Oyster shell is a biocompatible and biodegradable material and osteoconduction is the main healing style in the bone defects received by oyster shell.
出处
《浙江创伤外科》
2009年第5期437-439,共3页
Zhejiang Journal of Traumatic Surgery
基金
浙江省自然科学基金资助项目(编号:Y405476)
关键词
牡蛎壳
生物相容性
骨缺损
降解
Oyster shell
Biocompatibility
Bone defect
Degradation
