摘要
【目的】探讨术前全身新辅助化疗（NAC）对巨块型宫颈癌的疗效。【方法】选择2000年12月至2005年12月邵阳市中心医院初治病理确诊宫颈癌患者35例，采用PVB（顺铂50mg／m^2 d1＋长春新碱1mg／m^2 d1＋博莱霉素20mg／m^2 d1～d3）静脉化疗1～3疗程并化疗后15～20d行子宫广泛切除＋盆腔淋巴结清扫术（观察组）。与同期单纯手术的病人39例为对照组在术后病理及生存率等方面进行分析对比。【结果】观察组患者化疗有效率为80．00％，所有病人阴道切缘均未见癌细胞，术后5年生存率为77．50％。而对照组患者阴道切缘有4例见癌细胞，5年生存率为52．49％，两者对比差异有显著性（P〈0．05）。【结论】经术前全身辅助化疗配合妇科手术治疗宫颈癌可提高病人生存率。
[Objective] To investigate the effect of preoperative neoadjuvant chemotherapy（NAC） on Ⅰb2～Ⅱb b bullky cervical caner. [Methods] Thirty-five patients as observation group were selected at random to receive PVB intravenous chemotherapy （cisplatin 50mg/m^2 d1 plus vincristine 1mg/m^2 d1 plus bleomycin 20mg/m^2 d1-d3） for 1 to 3 courses, and then underwent extensive hysterectomy combined with pelvic lymphadenectomy. And 39 patients undergoing single surgery at the same time were selected as control group. The pathological change and survival rate after operation were analyzed and compared. [Results] In the observation group, the complete response rate was 80.00% and no cancer cell was found in vaginal incision margin in all patients. In the control group, cancer cells were found in vaginal incision margin in 4 patients. The 5 year survival rate of the two group was 77.50% and 52.49%0, respectively, and there was statistical significance （ P 〈0.05）. [Conclusion] Preoperative NAC combined with gynecological surgery can improve the survival rate of the patient suffering from cervical cancer.
出处
《医学临床研究》
CAS
2009年第10期1892-1894,共3页
Journal of Clinical Research
