摘要
目的观察预防性口服氯化镁对实验性心肌缺血的保护作用。方法用结扎清醒大鼠左冠状动脉（ＬＡＤ）前降支致急性心肌梗塞（ＡＭＩ）模型。结果预防性口服氯化镁能显著缩小心肌梗塞范围，降低血清磷酸肌酸激酶（ＣＰＫ）、天门冬氨酸氨基转移酶（ＡＳＴ）活性，提高血清钾、镁浓度，减轻清醒大鼠缺血早期心律失常。
AIM To observe the protective effects of peroral magnesium chloride on experimental myocardial ischemic injury. METHODS Experiments were performed on the model of acute myocardial infarction in conscious rats whose anterior descending branch of left coronary artery were ligated. RESULTS Peroral magnesium chloride can reduce myocardial infarct zone, lower the activity of creatine phosphate kinase (CPK),AST, increase serum Mg2+ and serum K+ and lighten the early ischemic arrhythmia in conscious rats. CONCLUSION Peroral magnesium chloride can antagonize the experimental myocardial ischemic injury effectively. The effects of magnesium chloride are due to reducing the early ischemic arrhythmia and lessening myocardial infarct zone.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1998年第3期253-255,共3页
Chinese Pharmacological Bulletin
基金
辽宁省科委科研基金
关键词
氯化镁
心肌梗塞
心肌缺血
药物疗法
magnesium chloride
conscious rats
myocardial infarction
arrhythmia
