摘要
目的探讨熊去氧胆酸(UDCA)治疗婴儿肝炎综合征(IHS)的疗效。方法85例IHS患儿随机分为治疗组45例(男23例,女22例;平均年龄2.35个月)与对照组40例(男21例,女19例;平均年龄2.05个月)。二组病例均予保肝及基础治疗。治疗组在此基础上,加用UDCA15～25mg/(kg.d),分2、3次服用,连续应用10～15d为1个疗程,部分用2、3疗程。监测二组患儿治疗前后血清与十二指肠引流液(胆汁)中总胆红素(TB)、结合胆红素(DB)、ALT、γ-谷氨酰转肽酶(γ-GT)、总胆汁酸(TBA)水平以及肝脏大小。采用SPSS11.0软件进行统计学分析。结果采用UDCA治疗2周后,治疗组患儿血清及胆汁中TB、DB、ALT、γ-GT、TBA与对照组比较均显著降低(Pa<0.01),肝脏明显缩小(P<0.01);十二指肠引流液中TB、DB、TBA均较对照组显著升高(Pa<0.01),二组治疗后十二指肠引流液中ALT无显著性差异。二组均未见明显药物不良反应。结论UDCA能降低血清胆红素及内源性胆汁酸水平,可促进胆红素、TBA排泄,具有明显的利胆、退黄的疗效。
Objective To explore the curative effect of ursodeoxyeholic acid （UDCA） on infantile hepatitis syndrome （IHS）. Methods Eighty - five IHS children were randomly divided into treatment group [ n = 45,23 boys and 22 girls, whose average age was 2.35 months, receiving the basic therapies such as liver protection therapy, and so on, and UDCA therapy with 15 -25 mg/（ kg · d） , 10 - 14 days as a course of treatment, and someone for 2 -3 courses of treatment ] and control group （n = 40,21 boys and 19 girls, whose averageage was 2.05 months, only receiving the basic therapies as mentioned above）. Total bilirubin （TB） , direct bilirubin （DB） , alanine aminotransferase （ALT）, γ- glutamyhranspeptidase（ γ- GT）, total bile acid （TBA） of the serum and intraduodenal drain （bile） and liver size were detected before and after the treatment. SPSS 11.0 software was used to analyze the data. Results Compared with control group,the levels of TB,DB, ALT, γ- GT, and TBA in serum of treatment group reduced significantly （P 〈 0.01 ） ,and the liver size reduced obviously （P 〈 0.01 ） ;while the level of TB ,DB and TBA in bile increased significantly （Pa 〈0.01 ）. There was no significant difference in the ALT level of bile between the 2 groups. The side effect of the 2 groups was not obvious. Conclusions UDCA can reduce the levels of serum bilirubin and endogenous bile acid,and promote the excretion of bilirubin and bile acid with cholagogic effect and jaundice elimination.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2009年第19期1499-1500,1503,共3页
Journal of Applied Clinical Pediatrics
关键词
婴儿肝炎综合征
熊去氧胆酸
治疗
infantile hepatitis syndrome
ursodeoxycholic acid
therapy
