摘要
目的探讨支气管哮喘血浆内皮素－１（ＥＴ１）含量及肺功能关系。方法采用特异性放射免疫技术测定支气管哮喘急性期２６例，缓解期２３例和健康对照组２２例的血浆ＥＴ１含量，测定肺功能。结果哮喘急性期ＥＴ１含量（７１．２±７．６４ｎｇ／Ｌ）显著高于缓解期（３８．６２±８．２２，Ｐ＜０．０１）和对照组（３５．１１±９．８１，Ｐ＜０．０１），缓解期和对照组ＥＴ１之间差异无显著性（Ｐ＞０．０５），急性期ＥＴ１含量与第一秒用力呼气量占预计值百分比、最大呼气中段流速呈显著负相关（ｒ＝－０．８１９７，ｒ＝－０．８２３６，Ｐ＜０．０１）。结论ＥＴ１和支气管哮喘急性发作有关，并影响肺功能。
Objective\ To evaluate the relationship between plasma endothelin 1 and pulmonary function in asthma \ Methods\ Plasma endothelin 1 were determined by radioimmunoassay in 26 cases of acute attack of asthma,23 subjects of non symptomatic asthma(remission group) and 22 normal volunteers(control group) \ Results\ The results showed that the plasma ET 1 in attack group(ET 1,71 21±7 64 ng/L) were higher than both remission group(ET 1,38 62±8 22,P<0 01) and control group(ET 1,35 11±9 81,P<0 01) \ However,no significant difference of ET 1 was found between remission group and control group \ The plasma ET 1 level revealed notably negative correlation to FEV1% and MMEF(r=-0 8197,r=-0 8236,P<0 01) \ Conclusion\ The results suggested that ET 1 pro bably plays certain role in acute attack of asthma and affects pulmonary function
出处
《福建医科大学学报》
1998年第4期364-366,共3页
Journal of Fujian Medical University
