摘要
目的探索影响环孢素A(CsA)血药浓度的因素,为临床合理用药提供参考。方法以国内外现有相关文献为基础进行分析和归纳。结果移植器官、肝功能、胃肠道功能、术后时间、饮食、给药方法、药物剂型和质量、合并用药等均可影响CsA的血药浓度。结论影响CsA血药浓度的因素很多,临床应用CsA时应结合患者实际情况定期进行血药浓度监测,及时调整用药方案,以确保患者用药的安全、有效。
Objective To observe the factors influencing the serum concentration of cyclosporin A （CsA） and to offer reference to the rational use of drugs. Methods The present domestic and international materials were analyzed and summed up. Results These influencing factors included transplanted organs, functions of liver and gastrointestinal tract, postoperative time, food and beverage, methods of administration, dosage forms and quality of drug and combining use of drugs. Conclusion According to the patient＇s actual conditions, doctors should regularly carry on therapeutic drug monitoring, adjust the scheme of using medicine in time and ensure the patients in their safe and effective use of drug.
出处
《中国药业》
CAS
2009年第21期1-3,共3页
China Pharmaceuticals
关键词
环孢素
血药浓度
影响因素
cyclosporin A
serum drug concentration
influencing factor
