摘要
目的：探讨计算降压谷峰比率的可靠方法。方法：３３例轻～中度原发性高血压患者，服安慰剂２周后，随机分入氨氯地平（ＡＭ）组（ｎ＝１６）与硝苯地平控释片（ＮＩ）组（ｎ＝１７）治疗４周。以诊室血压与动态血压监测评价降压效果，采用不同方法计算降压峰值、谷值、谷峰比率。结果：两组血压均显著降低。不同方法计算的峰值间差异较大。以２小时时段法及在２４小时内计算的２小时峰值较大，降压峰值及达峰时间的个体变异均较大。不同方法计算的谷值间无显著差异。ＡＭ组总体方法计算的收缩压、舒张压谷峰比率分别为６３％、５５％，个体方法计算的收缩压、舒张压谷峰比率分别为（３０±４２）％、（２５±４８）％；ＮＩ组总体方法计算的收缩压、舒张压谷峰比率分别为８５％、８１％，个体方法计算的收缩压、舒张压谷峰比率分别为（５５±３４）％、（５２±４２）％。结论：降压峰值及达峰时间的个体间变异均较大，在２４小时内计算２小时峰值是较可靠的方法，总体计算法高估谷峰比率，个体计算法较好。
Objective: To search for the best method of calculating trough:peak ratio. Methods:Thirty three patients with mild to moderate essential hypertension were studied.After 2 week's treatment with placebo,they were randomizedly treated with amlodipine (AM, n =16)or nifedipine gastrointestinal therapeutic system(GITS)(NI, n =17)for a further 4 weeks.The efficacy of drugs were evaluated by office blood pressure and ambulatory blood pressure monitoring.Trough value,peak value and trough:peak ratio were calculated by different methods. Results:The blood pressure decreased significantly in both groups.There were significant differences between peak values calculated by different methods.The peak value and time to peak of individual subjects varied greatly.The trough values were similar when computed by different methods.In AM group,the systolic blood pressure and diastolic blood pressure trough:peak ratios calculated by global method were 63% and 55% respectively,that calculated by individual method were (30±42)% and (25±48)% respectively.In NI group,they were 85%,81% and (55±34)%,(52±42)% respectively. Conclusion:The peak value and time to peak of individual subjects varied significantly.The peak values calculated over 2h in the whole 24 hours interval of dosing by individual approach is better.The global approach might lead to overestimation of trough:peak ratio.
出处
《中国循环杂志》
CSCD
北大核心
1998年第6期324-327,共4页
Chinese Circulation Journal
关键词
降压药
降压谷峰比率
计算
高血压
药物疗法
Hypertension
Ambulatory blood pressure monitoring
Trough:peak ratio
