摘要
目的:探讨经鼻持续气道正压通气(nCPAP)对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者心率变异性(HRV)的影响。方法:分析2005年9月至2008年10月间在贵州省人民医院进行多导睡眠图及动态心电图检测的26例OSAHS患者及28例健康对照者,计算夜间平均正常RR间期标准差(SDNN),相邻RR间期的均方根(rMMSD)以及低频(LF)、高频(HF)和LF/HF值,分析HRV。其中OSAHS患者在nCPAP治疗1年后予复查多导睡眠图及动态心电图。结果:OSAHS组夜间SDNN、夜间rMMSD分别为(83.4±26.4)、(31.0±9.7)ms,与对照组的(115.6±31.2)ms和(42.8±13.1)ms比较,均明显降低(P<0.05)。OSAHS组的LF、HF和LF/HF值分别为(556.3±181.9)、(214.9±63.6)ms2和3.6±1.2,与对照组的(396.7±127.2)、(307.5±101.4)ms2和1.9±0.6比较,差异有统计学意义(均P<0.05)。OSAHS组nCPAP治疗后呼吸紊乱指数、SDNN、rMMSD、LF、HF和LF/HF值均比治疗前改善(P<0.05)。结论:OSAHS患者合并HRV异常,nCPAP在改善通气的同时,也改善患者的HRV。
Objective To investigate the effect of nasal continuous positive airway pressure （nCPAP） on heart rate variability （HRV） in patients with obstructive sleep apnea and hypoventilation syndrome （OSAHS）. Methods 26 patients with OSAHS （OSAHS group） who had received polysomnography （PSG） and dynamic cardiography （DCG） from Sep 2005 to Oct 2008 and 28 normal controls （control group） were included. Mean night standard deviation of RR interval （SDNN）, mean night root-mean-square standard deviation of RR interval （rMMSD）, mean night low frequenee （LF）, mean night high frequence （HF） and their ratio （LF/HF） were calculated. Results Mean night SDNN and rMMSD were significantly lower in OSAHS group than in control group [ （83.4 ± 26.4）ms vs （115.6 ± 31.2） ms; （31.0 ± 9.7）ms vs （42.8 ± 13.1）ms; P 〈 0.05]. There were statistical differences in LF, HF, and LF/HF between OSAHS group and control group [（556.3 ± 181.9）ms2 vs （396.7 ± 127.2）ms2; （214.9 ± 63.6）ms2 vs （307.5 ± 101.4）ms2; 3.6 ± 1.2 vs 1.9 ± 0.6; P 〈 0.05]. After nCPAP treatment, the apnea hyponea index （AHI）, mean night SDNN and rMMSD, LF, HF, and LF/HF were significantly changed in patients with OSAHS （P 〈 0.05）. Conclusion There is an obvious abnormality of HRV in patients with OSAHS, nCPAP can both improve the ventilation and modify the HRV in patients with OSAHS.
出处
《实用医学杂志》
CAS
北大核心
2009年第20期3407-3409,共3页
The Journal of Practical Medicine
基金
贵州省科技攻关基金资助项目[编号:黔科合NY字(2006)3060]
关键词
睡眠呼吸暂停
阻塞性
心率变异性
经鼻持续气道正压通气
Sleep apnea, obstructive
Heart rate variability
Nasal continuous positive airway pressure
