摘要
目的研究胰腺炎对肝衰竭患者血细胞、肝肾功能及预后的影响。方法以肝衰竭并发急性胰腺炎病例为研究组,回顾性分析并发胰腺炎前后血常规、肝肾功能变化情况,随机抽取同时期非并发胰腺炎的肝衰竭患者为对照组,分析两组严重并发症的发生率及病死率。结果发生急性胰腺炎后红细胞及血红蛋白明显下降(t=4.088,P=0.000;t=3.419,P=0.002),血清总胆红素明显升高(t=2.063,P=0.048),出现明显的肾功能损害,血清尿素氮、肌酐明显升高(t=3.172,P=0.004;t=3.183,P=0.004),发生急性胰腺炎增加了肝肾综合征的发生率(39.4%vs3.0%,t=13.055,P=0.000),以及病死率(69.7%vs42.4%,t=4.982,P=0.026)。结论肝衰竭并发急性胰腺炎使得病情严重,易发生肝肾综合征,病死率增高。
Objective To study the influence of acute panereatitis on haemocyte, liver function, renal function, and prognosis of patients with liver failure. Methods 33 patients with liver failure complicated with acute pancreatitis were retrospectively analyzed for the hematological features, liver function and renal function before and after presenting with acute pancreatitis. 33 control patients with liver failure without acute pancreatitis were recruited during the same period. The differences of incidence rate of severe complication and fatality rate between these two groups were analyzed. Results Patients in the research group had a significantly lowered red blood cell count （t=4.088 ,P= 0.000） and hemoglobin content （t=3.419,P=0.002）. The levels of total bilirubin （t=2.063,P=0.048）, serum urea nitrogen （t=3.172,P=0.004） and creatinine （t=3.183,P=0.004） were also increased. Patients in the research group also had a higher incidence rate of hepatorenal syndrome （39.4% vs 3.0% ,t=13.055,P=0.000） and fatality rate （69.7% vs 42.4%,t=4.982,P=0.026） than those in control group. Conclusion The pathological conditions of patients with liver failure became severe if these patients had acute pancreatitis at the same time, These patients may also develop hepatorenal syndrome and the fatality rates may increase.
出处
《热带医学杂志》
CAS
2009年第9期1032-1034,共3页
Journal of Tropical Medicine
关键词
胰腺炎
急性
肝衰竭
预后
pancreatitis, acute
liver failure
prognosis
