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香菇和黄芪混合多糖抑制S-180肉瘤生长和增强免疫作用的研究 被引量:5

Inhibitory effects of Lentinan and Astragalus Polysaccharides on Tumour
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摘要 经口给予香菇多糖与黄芪多糖混合物,抑制动物移植性肿瘤重复实验结果一致显示,香菇多糖与黄芪多糖混合物在150.0mg/kg.BW/d剂量时可以抑制S—180移植性肉瘤的生长;小鼠腹腔巨噬细胞吞噬鸡红细胞作用实验显示,香菇多糖与黄芪多糖混合物在37.5mg/kg.BW/d剂量(及以上剂量)时具有提高小鼠吞噬细胞功能的作用;小鼠脾NK细胞活性测定结果表明,香菇多糖与黄芪多糖混合物在37.5mg/kg.BW/d剂量(及以上剂量)时具有增强NK细胞活性的作用。 It was reported in this article that inhibitory effects of Lentinan and Astragalus polysaccharides on tumour growth was found on mice. The experimental result indicated that the mixture substance of Lentinan and Astragalus polysaccharides at the dose of 150.0mg/kg. BW/d could inhibit the growth of S 180 sarcoma. The study of peritoneal macrophage phagocytosis on cock's RBC in mice indicated that the mixture substance of Lentinan and Astragalus polysaccharides at the dose of 37.5mg/kg. BW/d (and above this dose) could enhance phagocytosis of macrophage in mice. And we also found that the mixture substance of Lentinan and Astragalus polysaccharides at the dose of 37.5mg/kg.BW/d(and above this dose) could enhance the activation of natural killer cell. The result of these three experiments had excellent dose response relationship. We considered the mixture substance of Lentinan and Astragalus polysaccharides had inhibitory effect on tumour growth.
出处 《预防医学情报杂志》 CAS 1998年第4期210-213,共4页 Journal of Preventive Medicine Information
关键词 香菇多糖 黄芪多糖 NK细胞 免疫增强剂 Lentinan Astragalus polysaccharide tumour inhibition S 180 sarcoma macrophager
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