摘要
将合成的含有羧基侧基官能团的己内酯类聚合物,用溶剂挥发与超声乳化相结合的方法制备成表面可供修饰的纳米粒子.利用扫描电镜(SEM)研究了纳米粒子在水溶液中的形态.使用5-氟脲嘧啶(5-FU)作为模型药物制备了载药纳米粒子,利用紫外分光光度计法、差示扫描量热法(DSC)、X射线衍射法(XRD)研究了纳米粒子的载药及释放性能.研究表明,载药纳米粒子可以控制5-FU的释放速率.释放时间可持续至96h以上,符合Higuchi动力学方程.
Carboxylic poly（ε-caprolactone） nanoparticles have been prepared by a emulsification/solvent evaporation method. The morphologies of the nanoparticles were investigated by scanning electron microscope （SEM）. 5-Fluorouracil was employed as a model drug for the fabrication of drug loaded nanoparticles. UV spectrometer, differential scanning calorimeter （DSC） and X-ray diffraction （XRD） were adopted to study the entrapment and release behaviour. The results revealed that the release behaviour of 5-FU could be well controlled. The release could last for more than 96 h, and the release behaviour accorded with Higuchi kinetics equation.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2009年第19期2205-2209,共5页
Acta Chimica Sinica
基金
国家自然科学基金(Nos.20674019
20804015)
博士点基金(Nos.20060251015
200802511021)
上海市曙光学者计划
上海市自然科学基金(No.08ZR1406000)
上海市重点学科建设项目(No.B502)资助项目
