摘要
以两倍稀释法测定氟甲砜霉素及甲砜霉素对鸡巴氏杆菌的最小抑菌浓度分别为０．２５μｇ／ｍＬ和１．２５μｇ／ｍＬ。按１０，２０和３０ｍｇ／ｋｇ的氟甲砜霉素及３０ｍｇ／ｋｇ的甲砜霉素分别给实验性巴氏杆菌病患鸡肌注，每天给药一次，共５ｄ。药物对鸡巴氏杆菌病的治愈率分别为９３．３％，１００％，１００％和１００％，而感染对照组鸡全部死亡。
Minimal inhibitory concentrations (MICs)of Florfenicol and thiamphenicol for Pasteurella
multocide were determined by two-fold dilation method in vitro.Then,the therapeutic trials of
florfenical(10,20 and 30 mg/kg)and thiamphenicol(30 mg/kg)against experimentally induced
pasteurellosis were carried out in fowl following imtramuscular administration for 5 successive
days(one daily).The inhibitory tests in vitro showed that MICs of florfenicol and thiamphenicol
were 0.25 and 1.25 μg/mL for pasteurella multocide,respectively.Following treatment with
florfenicol(15,10 and 20 mg/kg)and thiamphenicol (30 mg/kg)against pasteurellosis for 5
days,the curative rates of the drugs for pasteurella multocide-infected fowl were
93.3%,100%,100% and 100%,respectively.In infected group,the mortality of fowl was 100%.The
result shows that florfenicol have a good therapeutic index in the control of pasteurellosis in
fowl.
出处
《中国家禽》
北大核心
1998年第12期13-14,共2页
China Poultry
