摘要
目的：观察中脑楔状核（ＮＣＦ）尾部给予外源性吗啡对延髓中缝大核（ＮＲＭ）和中脑导水管周围灰质（ＰＡＧ）内痛兴奋神经元（ＰＥＮ）的痛放电影响。方法：用玻璃微电极细胞外记录方法，分别在ＮＲＭ和ＰＡＧ内记录ＰＥＮ的单位放电。结果：（１）ＮＣＦ内注入吗啡（３×１０－２ｍｏｌ／Ｌ）能明显抑制ＰＡＧ、ＮＲＭ内ＰＥＮ的痛放电频率；（２）ＮＣＦ内微量注入纳洛酮（２．７４×１０－３ｍｏｌ／Ｌ）能增加ＰＡＧ、ＮＲＭ内ＰＥＮ的痛放电频率；（３）ＮＣＦ内预先注射纳洛酮（５．５×１０－３ｍｏｌ／Ｌ）能部分阻断吗啡对ＰＡＧ、ＮＲＭ内ＰＥＮ痛放电抑制效应。结论：ＮＣＦ内某些神经元与抗伤害性感受有关；
Objective:To explore the effect of microinjecting morphine of naloxone into nucleus cuneiformis(NCF) on the frequencies of evoked discharge of pain excitation neurons (PEN) in periaqueductal gray(PAG) or nucleus raphe magnus(NRM).Methods:The extracellular recording method was used to investigate the effect of the antinociceptive role of opioids in NCF.Results:(1)Intra NCF injection of morphine(3×10 -2 mol/L,n=8) could suppress the frequencies of evoked discharge of PEN in PAG or NRM ( P <0 001,0 01,0 05),the maximal inhibitory rate was (77 3±7 5)% and (78 4±7 0)% respectively;(2)Naloxone(2 74×10 -3 mol/L,n=8)injected into NCF could enhance the evoked discharges of PEN in PAG and NRM( P <0 01,0 05),the percentage of change in the frequence of evoked discharge increased by (82 9±4 1)% and (79 5±3 1)% respectively.(3)Both of the above mentioned inhibitory effects of morphine (n=8) could be antagonised by intra NCF preinjection of naloxone (5.5×10 -3 mol/L,n=8)( P <0 001)。Conclusion:Some neurons in NCF might participate in the process to modulate noxious information transmission in CNS.Endogenous opiate might be a neuromodulator or transmitter in the antinociception of NCF.Both of the inhibitions of morphine injected into NCF on the PEN in PAG or NRM may be mediated by opioid receptor.
出处
《滨州医学院学报》
1998年第6期526-529,共4页
Journal of Binzhou Medical University
关键词
楔状核
导水管周围灰质
中缝大核
痛调制
吗啡
neucleus cuneiformis
periaqueductal gray
nucleus raphe magnus
antinociception
morphine
