摘要
分别给予含醋酸铅０、１０、３０、９０、２７０、８１０ｍｇ／ｋｇ的饲料喂养幼年ＳＤ大鼠连续８周，用碱性磷酸酶抗碱性磷酸酶法（即ＡＰＡＡＰ法）测定了经８周不同剂量铅暴露后大鼠Ｔ细胞亚群（ＣＤ４、ＣＤ８）的分布，并用原子吸收石墨炉法测定血铅。结果显示：各剂量铅暴露组血铅明显升高，Ｔ细胞亚群分布异常，ＣＤ４减少，ＣＤ４／ＣＤ８降低，并随着各组血铅浓度的升高而减少；ＣＤ８亚群各组间无明显差异。提示：长期低铅染毒可影响大鼠Ｔ细胞亚群的分布。
Sixty SD rats were fed on diets with lead acetate (PbAc 2) at doses of 0, 10, 30, 90, 270 and 810 mg/kg for 8 weeks. Blood lead concentration was detected by atomic absorption spectrophotometry and T lymphocyte subsets (CD 4, CD 8) by the APAAP assay after the exposure. The results showed that levels of blood lead significantly enhanced and the number of CD 4 T cell, the ratio of CD 4/CD 8 decreased in the experimantal groups. And there was negative correlation between blood lead level and number of CD 4 T cell, the ratio of CD 4/CD 8. It suggested that long term lead exposure would exert influence on the distribution of T lymphocyte subsets.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
1998年第6期495-497,共3页
Journal of Nanjing Medical University(Natural Sciences)
