摘要
目的：为了探讨神经肽降钙素基因相关肽和内皮素１在ＳＬＥ活动期中的作用。方法：采用放射免疫分析法测定了３４例系统性红斑狼疮病人和２０例健康人血浆ＥＴ１、ＣＧＲＰ水平。结果：有抗ｄｓＤＮＡ抗体升高和补体Ｃ３、Ｃ４下降的ＳＬＥ组，ＥＴ１水平升高（Ｐ＜００１），ＣＧＲＰ水平降低（Ｐ＜００５）。治疗三个月后，ＥＴ１水平无明显差异（与治疗前比Ｐ＞００５）。ＣＧＲＰ有明显差异（与治疗前比Ｐ＜００５）。直线相关分析表明，血浆ＥＴ１与ＣＧＰＲ呈显著负相关。结论：提示ＥＴ１与ＣＧＲＰ失衡可能是ＳＬＥ活动期发生、发展的重要因素。测定血浆ＥＴ１、ＣＧＲＰ水平变化可望作为判断病情严重程度和治疗好坏的一个指标。此结果为应用ＣＧＲＰ治疗ＳＬＥ的理论提供依据。
Objective:To investigate effect of CGRP and ET 1 in patients with active SLE.Methods:The plasma levels of CGRP and ET 1 in 34 patients with SLE and 20 normal controls were measured using radioimmunoassay method.Results:The patients with SLE having significantly high level of anti dsDNA antibody and lower level of C 3 and C 4 have significantly increased levels of plasma ET 1 ( P <0 01) and descended levels of plasma CGRP ( P <0 05).After 3 month treatment,the plasma ET 1 level of patients with SLE has not been significantly changed ( P >0 05) and the plasma CGRP level has been significantly changed ( P <0 05).There were negative correlations between the plasma levels of ET 1 and CGRP.Conclusion:ET 1 and CGRP may play an important role in the development of active SLE.The changes of plasma levels of ET 1 and CGRP may be regarded as indicators of the disease severity and the rapeutic effect.The result may provide theoretical evidence for CGRP being used to treat the patient with SLE.
出处
《中华风湿病学杂志》
CAS
CSCD
1998年第3期161-163,共3页
Chinese Journal of Rheumatology
关键词
内皮素
降钙素
基因相关肽
系统性红斑狼疮
endothelins calcitonin gene related peptide systemic lupus erythematosus,systemic
