摘要
用邻－、对－氨基苯甲酸修饰二乙三胺五乙酸（ＤＴＰＡ），分别得到两种分子中携带芳香基团的双酰胺型ＤＴＰＡ衍生物，合成了它们的顺磁性金属离子螯合物，并研究了其中部分螯合物的ｉｎｖｉｔｒｏＮＭＲＴ１弛豫率（Ｒ１）．结果表明，Ｇｄ（Ⅲ）ＤＴＰＡ－Ｂ４ＡＢＡ２－和ＧｄＤＴＰＡ－Ｂ２ＡＢＡ２－对水质子的弛豫率Ｒ１分别为５．５和５．４Ｌ·ｍｍｏｌ－１·ｓ－１，接近相应的母体螯合物ＧｄＤＴＰＡ２－的Ｒ１值５．２Ｌ·ｍｍｏｌ－１·ｓ－１．
Two new DTPA diamide derivatives bearing two aromatic moieties have been obtained by a modification of DTPA(diethylenetriaminepentaacetic acid) with p and o aminobenzoic acid. Their gadolinium, ytterbium, and iron complexes have been synthesized and some of them were examined for the role as the contrast agents for magnetic resonance imaging. The results show that the NMR T 1 relaxivitives( R 1 ) for Gd(Ⅲ) DTPA B4ABA 2- and Gd(Ⅲ) DTPA B2ABA 2- in water solutions are 5.5 and 5.4 L\5mmol -1 \5s -1 , respectively, which are higher than that of their parent complex, GdDTPA 2- .
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1998年第10期1593-1596,共4页
Chemical Journal of Chinese Universities
基金
国家863计划
中国博士后科学基金
关键词
氨基苯甲酸
钆螯合物
造影剂
MRI
DTPA
肝胆靶向
Diethylenetriaminepentaacetic acid, Aminobenzoic acid, Modification, Gadolinium chelate, Magnetic resonance imaging contrast agent
