摘要
目的比较IFP方案和(TAX+IFP方案)分别治疗晚期胃癌临床疗效和毒性反应。方法将59例病例按随机分配原则分为对照组(IFP方案)30例和观察组(TAX+IFP方案)29例。比较2组近期疗效和毒性反应。结果对照组和观察组总有效率分别为38.10%和68.97%。2组总有效率相比,差异有统计学意义(P<0.05)。2组毒副反应主要为骨髓抑制、关节肌肉痛、神经毒性、消化道反应及脱发等。两组毒副反应比较,差异无统计学意义(P>0.05)。结论紫杉醇(TAX)联合醛氢叶酸(LV)、氟尿嘧啶(5-Fu)、顺铂(DDP)治疗晚期胃癌有较好的临床治疗效果,毒性可以耐受。
Objective And （the TAX ＋ IFP plan） treats the later period stomach cancer clinical curative effects and the toxic response separately compared with the IFP plan. Methods Divides into the control group 59 example cases according to the random distribution principle （the IFP plan） 30 cases and the observation group （the TAX ＋ IFP plan） 29 cases. Compared with 2 group of short-term curative effects and toxic response. Results The control group and observation group total effectiveness respectively were 38. 10% and 68.97%. two groups of total effectiveness compared, the difference has statistics significance （ P 〈 0.05 ） 2 groups of poisonous side reactions mainly suppress, the joint courbature, the nerve toxicity, the digestive tract for the marrow to respond and to lose hair and so on. Two group of poisonous side reaction comparisons, the difference were not have the significance （P 〉 0. 05 ）. Conclusion Taxus mellow （TAX） union aldehyde hydrogen folic acid （LV） ,the fluorine uracil （5-Fu） ,has the good clinical care effect along the platinum （DDP） treatment later period stomach cancer, the toxicity may endure.
出处
《中国实用医药》
2009年第28期9-10,共2页
China Practical Medicine
关键词
TAX
晚期胃癌
化疗
疗效
毒性反应
TAX
Later period stomach cancer
Chemotherapy
Curative effect
Toxic response
