摘要
目的通过检测血栓的蛋白指标，回顾性分析易栓症病人发病的病因，预防血栓的再次发生。方法收集2004年-2007年住院病人136例，其中肺动脉栓塞病人96例，心肌梗死病人30例，心肌梗死并发高血压的病人3例，下肢深静脉血栓病人7例。另选25例健康体检者为对照组，采用凝固法测定蛋白S（PS：A）、蛋白C（PC：A）、狼疮抗凝物（LA）、APC抵抗（APC-R）；采用发色底物法检测抗凝血酶Ⅱ（AT—Ⅱ）、纤溶酶原（PLG），用Clauss法检测纤维蛋白原（FIB）。结果心梗和肺动脉栓塞病人的易栓症指标和正常对照组比较，PC：A，PS：A，LA，APC—R易栓症组比对照组活性明显降低差异有统计学意义（P〈0．01），而AT—Ⅱ，FIB，PLG易拴症组和对照组比较差异没有统计学意义（P〉0．05）。结论研究结果显示，PS：A，PC：A，LA，APC—R可作为临床血栓病人的重要监测指标。
Objective To detect protein target of thrombus,investigated blood coagulation and fiber lysis tests including protein S activity （PS ： A）, protein C activity （PC ： A）, activated protein C-resistant, antithrombin- Ⅱ , plasminogen, lupus antieoagulant,fibrinogen in thrombophilia patients. Methods Blood samples of 136 patients in our hospital were collected,among them there were 96 pulmonary embolism patients, 30 myocardial infarction patients, 3 hypertensive disease patients and 7 deep vein thrombosis patients. PS： A, PC：A, APCR, LA were measured by coagulation-based assay, AT-Ⅱ , PLG were measured by chromogenic substrate assay, FIB was measured by Clauss assay. Results Compared with normal group,PC：A and PS：A in myocardial infarction and pulmonary thromboembolism patients were significantly decreased （P 〈0. 01） ,LA was remarkably increased （P〈0. 01） ,APCR was remarkably decreased （P〈0.01） ,but AT- Ⅱ ,PLG and FIB had no significant difference（P〉0. 05）. Conclusion Results of the present study show that,PS：A,PC：A,LA,APC-R can be used as an importance monitoring indicators of clinical for pateints with thrombosis.
出处
《现代检验医学杂志》
CAS
2009年第5期138-139,共2页
Journal of Modern Laboratory Medicine
关键词
血栓
易栓症
血栓蛋白指标
thrombus
t hrombophilia
proteintarget
