摘要
目的观察益气活血颗粒对原发性高血压患者血浆醛固酮、血管紧张素Ⅱ浓度的影响，并探讨其作用机制。方法将200例原发性高血压患者随机分为两组，常规降压组100例，给予常规降压治疗；联合治疗组100例，在常规降压治疗基础上加益气活血颗粒治疗，疗程均为4个月。分别检测治疗前后患者血压及血液中醛固酮（ALD）、血管紧张素Ⅱ（AngⅡ）的浓度。结果益气活血颗粒能有效降低血压及循环血液中ADL、AngH的浓度。结论益气活血颗粒具有降低血压和抑制肾素-血管紧张素-醛固酮系统（RAAS）活性。
Objective To investigate the effects of yiqihuoxue granula on the concentration of aldosterone （ALD） and angiotensin （Ang Ⅱ） of plasma in essential hypertension patients ,and further study the mechanism of yiqihuoxue granula on decreasing blood pressure in essential hypertension patients. Methods Two hUndred patients with essential hypertension were randomly divided into two groups：100 patients in group A were given routine therapy;other 100 patients in group B were given routine therapy and yiqihuoxue granula. The concentration of aldosterone（ALD） and angiotensin Ⅱ（Ang Ⅱ） of plasma and myoeardium by radioirnmunoassay. Results Yiqihuoxue granula could decrease blood pressure and concentration of aldosterone （ALD） and angiotensin Ⅱ（Ang Ⅱ） of plasma in essential hypertension patients after 4 months treatment（ P 〈0. 05）. Condusions Yiqihuoxue granula could restrain RAAS activity,which could be the mechanism of yiqihuoxue granttla decrease blood pressure.
出处
《中国实用医刊》
2009年第20期21-21,28,共2页
Chinese Journal of Practical Medicine
