摘要
目的探讨老年高血压并高脂血症患者早期肾功能损害及其与股动脉粥样硬化的关系。方法选取158例老年高血压病患者,根据是否合并有高脂血症分成2组,分别观察比较其尿微量白蛋白(MA)、α1-微球蛋白(α1-MG)水平及超声检查股动脉内-中膜厚度(IMT)、动脉硬化斑块指数(PI)。结果高血压病合并高脂血症组的MA、α1-MG水平明显高于单纯高血压组,差异有统计学意义(P均<0.01),2组间IMT、PI的差异无统计学意义。进一步分析显示2组内MA、α1-MG阳性患者IMT及PI显著高于阴性患者(P<0.05或0.01)。结论高脂血症是高血压病患者早期肾脏损害的高危因素,检测MA可以预测早期动脉粥样硬化。
Objective To evaluate the correlation between microproteinuria and early kidney damage and femur arterial atherosclerosis in hypertension patients. Methods One hundred and fifty eight patients with hypertension were divided into 2 groups： with hyperlipaemia and without hyperlipaemia. The urinary micro-albumin （MA）, α1micro-globulin（α1-MG）, and the intima-media thickness （IMT）, plaque index （PI） of femur artery were observed and compared between the 2 groups. Results The MA and α1-MG levels in patients with hyperlipaemia were significantly higher than those in patients without hyperlipaemia. There were no significant differences in IMT and PI between 2 groups （P〈0.01）. IMT and PI in patients with MA or α1-MG were significantly higher than those without MA and α1-MG （P〈0.05 或 0.01）. Conclusion Hyperlipaemia is a risk factor of early kidney damage in hypertension patients and microproteinuria can be used to predict early atherosclerosis.
关键词
高血压
高脂血症
动脉硬化
尿微量白蛋白
Hypertension
Hyperlipidemia
Arteriosclerosis
Microproteinuria
