摘要
通过免疫组化LSAB法对62例胃癌标本进行EGF和EGFR同步检测，发现两者同步表达率为33．8％。两者同步表达的胃癌其恶性程度高，浸润程度深，易出现淋巴结转移。胃癌的发展过程中可能存在一种EGF-EGFR自泌机制，这一机制促使癌细胞自主失控生长，两者同步表达更能反映胃癌的生物学行为。
The synchronous expression of epidermal growth factors (EGF) and EGF receptors (EGFR) in 62 gastric carcinomas was studied by immunohistochemical LSAB method. The rate of synchronous expression of EGF and EGFR was 33. 8%. The gastric carcinoma with synchronous expression of EGF and EGFR was more malignant and invasive ,and liable to metastasis to lymph nodes . The result suggested that gastric carcinoma should have an EGF-EGFR autocrine mechanism . The autocrine mechanism might make the uncontrolled autogrowth of the carcinoma cells. The synchronous expression can be used as a useful marker for the assessment of the biological behavior of gastric carcinoma .
