摘要
以3,4-二羟基苯甲醛为起始原料,经苄基保护、Darzens环氧化、Lewis酸开环、NaBH4还原、催化加氢脱保护得到β-(3,4-二羟基苯基)-α-羟基丙酸异丙酯和β-(3,4-二羟基苯基)-α-羟基丙酸冰片酯,所得化合物的结构通过1HNMR、13CNMR,IR,MS证实.该方法操作简单、毒性低、产物易于纯化.
β-(3,4-Dihydroxyphenyl)-α-hydroxy propionic acid lsopropyl and proplonlc acid borneol esters have been synthesized by taking 3,4-dihydroxybenzaldehyde as a raw material, through its benzyl protection, darzens ring-oxidation, Lewis acid ring-opening, NaBH4 reduction, deprotection of the Bzl groups by catalytic hydropyrolysis. The structures of products have been characterized by ^1H NMR, ^13C NMR, IR and MS techniques. The method contains the merits of easy manipulation and low toxcity.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2009年第9期1466-1469,共4页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.20774107)
陕西省教育厅自然科学专项基金(No.2006B17)
陕西省"13115"科技创新工程重大科技专项(No.2007ZDK)资助项目