摘要
目的:制备用于抗结核治疗的含异烟肼药膜型镍钛金属支架,并考察主药体外溶出度。方法:采用聚氨基甲酸乙酯为成膜材料,加入异烟肼混合,于载药膜支架均匀涂铺上述混合物后取出烘干即得;以紫外分光光度法测定异烟肼含量并计算体外累积溶出百分率。结果:主药异烟肼检测浓度的线性范围为5.0～30.0μg.mL-1(r=0.9999),回收率为99.67%(RSD=1.06%);支架中异烟肼在前30min内快速释放,累积溶出百分率超过60%,随后8h保持了平稳溶出。结论:该制剂制备方法简单,质量可控。
OBJECTIVE： To prepare a nickel - titanium alloy stent coated by anti - tuberculotic isoniazid and study the dissolution of isoniazid in vitro. METHODS： The polyurethane which was used as film - former was mixed with isoniazid before being coated uniformly on the stent, then the stend was torrefied and dried so that the drug layer alloy stent was obtained. The content and accumulated dissolution in vitro of isoniazid from the stent was determined by ultraviolet spectrophotometry. RESULTS： The linear range of isoniazid was 5.0--30.0g·mL-1 （r = 0.999 9） and its recovery rate was 99.67% （RSD = 1.06%）.A high accumluated dissolution rate of isoniazid was achieved, over 60% within the first 30 minutes, followed by a sustained dissolution in the following 8 h. CONCLUSION： The preparation method of the stent is simple and the quality is controllable.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第28期2215-2216,共2页
China Pharmacy
关键词
镍钛金属支架
溶出度
异烟肼
Nickel- titanium alloy stent
Dissolution
Isoniazid
