摘要
目的：解决高浓度安乃近共存情况下，盐酸氯丙嗪的含量测定。方法：以溴麝香草酚蓝为反离子，甲苯为萃取溶剂，建立了复方安乃近微型灌肠剂中盐酸氯丙嗪的含量测定方法。结果：测定波长４０４±１ｎｍ，线性范围２０～１４０μｇ·ｍｌ－１。平均方法回收率１００．４％，ＲＳＤ＝１．６％。结论：基质及高浓度安乃近不干扰测定。由摩尔比法测得溴麝香草酚蓝与盐酸氯丙嗪缔合比为２∶１。
OBJECTIVES: To determine the content of chlorpromazine hydrochloride in the samples with high concentration of analginum. METHODS: The extraction spectrophotometry with bromothymol blue as counter ion had been established for the measurement of chlorpromazine hydrochloride. RESULTS: The absorbance at 404nm showed the linear relationship in range of 20-140 μg/ml, with mean recovery of 100.4% , RSD of 1.55% ( n =9). CONCLUSIONS: Both blank and analginum showed no interference. The molecule rate of bromothymol blue to chlorpromazine hydrochloride was 2∶1.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1998年第9期404-406,共3页
Chinese Journal of Hospital Pharmacy
关键词
盐酸氯丙嗪
复方安乃近
灌肠剂
比色法
chlorlpromazine hydrochloride, bromothymol blue,determination
