摘要
目的探讨急性脑梗死患者糖耐量减低与颈动脉粥样硬化的关系及其相关影响因素。方法将326例急性脑梗死患者根据病情分为糖尿病组（DM组）、糖耐量减低组（IGT组）、糖耐量正常组（NGT组），比较3组患者的临床资料、生化指标及颈动脉B超检查结果。结果IGT组和DM组体重指数、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL—C）、空腹血糖（FBG）比NGT组明显增高，IGT组和DM组颈总动脉内膜-中层厚度（IMT）、斑块检出率、内膜光滑性和连续性评分、中重度血管狭窄及颈动脉粥样硬化的发生率均明显高于NGT组，差异均有统计学意义（P〈0．05）。Logistic多元回归分析结果显示年龄、TC、LDL-C、餐后2h血糖是颈动脉粥样硬化发生的独立危险因素。结论急性脑梗死患者中，合并IGT人群已经存在明显的颈动脉粥样硬化病变，其程度与DM类似。
Objective To investigate the relationship between impaired glucose tolerance （IGT） and carotid atheromatous plague in patients with acute cerebral infarction and analyze the risk factors for plaque formation. Methods The 326 patients hospitalized in our department for acute cerebral infarction were divided into diabetes mellitus （DM） group, IGT group and normal glucose tolerance （NGT） group. The clinical features, biochemical indices and results of Doppler ultrasound examination of the carotid artery were compared between the 3 groups. Results The body mass index （BMI）, total cholesterol （TC）, and low-density lipoprotein cholesterol （LDL-C） of IGT group were markedly higher than those in NGT group （P〈0.05）. Both the IGT and DM group showed significantly increased carotid intimal-medial thickness, plaque detection rate and the incidence of carotid scleratheroma in comparison with the NGT group （P〈0.05）. Logistic regressive analysis identified age, TC, LDL-C and 2-h postprandial serum glucose as the independent risk factors for carotid scleratheroma. Conclusion In patients with acute cerebral infarction, those having impaired glucose often show obvious carotid scleratheroma with a severity similar to that in the DM patients.
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2009年第9期920-922,共3页
Chinese Journal of Neuromedicine
关键词
脑梗死
糖尿病
糖耐量减低
颈动脉粥样硬化
Cerebral infarction
Diabetes mellitus
Impaired glucose tolerance
Carotid atheroselerosis
