摘要
目的比较喹硫平和舒必利对首发精神分裂症患者急性期生活质量的影响。方法符合国际疾病及有关健康问题分类第十版(ICD-10)关于精神分裂症诊断标准的200例首发患者随机分为2组,分别接受喹硫平或舒必利治疗8周。使用世界卫生组织编制的生活质量量表(WHO QOL-100)评定患者治疗前后的生活质量并作组间比较。结果喹硫平组患者治疗后第4周和第8周QOL-100的6个领域、19个方面和总的生活质量与健康状况的评分均高于治疗前,差异有统计学意义(P<0.01)。舒必利组患者治疗后第4周3个领域、15个方面和总的生活质量与健康状况评分好于治疗前,差异有统计学意义(P<0.05或P<0.01),第8周2个领域和10个方面明显改善(P<0.01)。治疗后第4周,两组仅在3个方面的评分差异有统计学意义(P<0.05或P<0.01)。治疗后第8周,两组在4个领域、总的生活质量与健康状况和12个方面评分的差异有统计学意义(P<0.05或P<0.01)。结论喹硫平和舒必利均能改善首发精神分裂症患者急性期的生活质量,但前者明显优于后者。
Objective To compare the effect of quetiapine and sulpiride on quality of life in the treatment of firstepisode schizophrenia. Methods A total of 200 first-episode patients met with the criteria of ICD-10 for schizophrenia were randomly divided into quetiapine group and sulpiride group for the treatment of 8 weeks. WHO Quality of Life scale（ WHO QOL-100） was used to assess quality of life. Results After 4 - week or 8 - week treatment, the scores of 6 domains, 19 aspects and the overall of quality of life in quetiapine group were significantly higher than those before treatment （P 〈 0. 01 ）. In sulpiride group, the scores of 3 domains, 15 aspects and the overall of quality of life at the end of 4th week,the scores of 2 domains and 10 aspects at the end of 8th week were significantly better than those before treatment（P 〈 0. 05 or 0.01 ）. After 4-week treatment, there were significant differences in 3 aspects of quality of life between two groups（P 〈0.05 or 0.01 ）. Significant differences in 4 domains, 12 aspects and the overall of quality of life were found between two groups after 8-week treatment （ P 〈 0. 05 or 0. 01 ）. Conclusions Quetiapine can have better effect on quality of life in first-episode patients with schizophrenia than sulpiride.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2009年第9期535-538,共4页
Chinese Journal of Nervous and Mental Diseases
