摘要
目的探讨非典型脑膜瘤(WHO grade II)临床病理特征及其对生存期的影响。方法收集2001年1月至2007年12月在中山大学肿瘤医院手术治疗并经病理确诊的、有完整临床随访资料的病例30例非典型脑膜瘤,应用Kaplan-Meier法、log-rank检验和Cox回归模型对其性别、年龄、肿瘤大小、Ki-67阳性率、P53阳性率、手术切除程度以及术后放疗等7项临床和病理特征进行单因素和多因素生存分析。结果患者中位年龄47岁,其中男9例,女21例。中位随访时间62个月(22～110个月)。平均复发时间为65个月(56～74个月),2年和5年无复发生存率分别为89%和62%。单因素和Cox多因素预后分析发现Ki-67表达和肿瘤大小两因素对生存期的影响有统计学意义(P<0.05)。结论肿瘤体积大、Ki-67高表达的非典型脑膜瘤患者容易复发,术后要严密随访。
Objective To investigate the clinicopathologic features and the impact of these factors on the survival time of atypical meningiomas （AMs） （ WHO grade II）. Methods A total of 30 definite cases of AMs with integrity clinical and follow-up information at the Cancer Center of Sun Yat-Sen Univercity between January 2001 and December 2007 were selected and seven factors including sex ,age ,tumor size,Ki-67 ,P53 ,resection degree and radiotherapy were analyzed by Kaplan-Meier method, log-rank analysis and Cox＇s proportional hazard regression model. Results The median age was 47 years and there were 9 men and 21 women. The median follow-up period was 62 months （range,22 -110 months）. The mean period of recurrence was 65 months （ range,56 -74 months） , recurrence-free survival （RFS） of 2 years and 5 years was 89% and 62% respectively. Simple analysis and multivariate regression analyses Showed that Ki-67 and tumor size were the risk factors affecting survival time （ P 〈 0. 05 ）. Conclusions AMs patients with large tumor size and high ex- pression of Ki-67 have high recurrent rate and they must be follow up frequently after therapy.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2009年第9期513-516,共4页
Chinese Journal of Nervous and Mental Diseases
关键词
非典型脑膜瘤
临床病理特征
生存分析
Atypical meningioma Clinicopathologic Features Survival analysis
