再生障碍性贫血克隆性演变研究的现状
摘要
随着再生障碍性贫血（AA）患者长期生存率逐年提高，AA转化为克隆性疾患，如阵发性睡眠性血红蛋白尿症（PNH）、骨髓增生异常综合征／急性髓系白血病（MDS／AML）呈增多趋势，且继发于AA的MDS／AML预后较原发性MDS／AML更差。作为AA晚期并发症之一，克隆性演变已成为影响其远期疗效的主要负面因素。本文就AA克隆性演变的发生率、危险因素、临床特征及其发生机制作一综述。
出处
《国际输血及血液学杂志》
CAS
2009年第5期428-432,共5页
International Journal of Blood Transfusion and Hematology
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