摘要
目的:制备紫杉醇纳米粒,并对其体外释药性能进行考察。方法:用开环聚合法合成壳聚糖-聚乳酸共聚物,采用纳米沉淀法制备包载紫杉醇的纳米粒,研究纳米粒的包封率和释药性能。结果:纳米粒呈球形,粒径均匀,药物包封率达到93.2%;体外模拟释放表明载药纳米粒的释药速率持续稳定。结论:本实验制备方法简便易行,制备的紫杉醇纳米粒具有明显的缓释作用。
Objective：To prepare paclitaxel nanoparticles and evaluate its drug release property in vitro. Methods： The chitosanpoly（lactide） eopolymers were synthesized by ring-opening polymerization. Paelitaxel nanoparticles were prepared by the nanopreeipitation method. The encapsulation efficiency of the nanoparticles and the in vitro release of paelitaxel were studied. Results ： The nanopartieles were fine and uniform spheres. The encapsulation efficiency of nanoparticles was up to 93.2%. The in vitro release profile showed the slow and stable release rate of paelitaxel. Conclusion： This method is simple and the nanopartieles possess good physical performance as sustained release character in vitro.
出处
《中药材》
CAS
CSCD
北大核心
2009年第9期1447-1449,共3页
Journal of Chinese Medicinal Materials
关键词
紫杉醇
纳米粒
包封率
体外释放
Paclitaxel
Nanoparticles
Encapsulation efficiency
In vitro release
