摘要
本文介绍了心脏移植治疗心衰的历史背景。心脏移植自60年代南非做的第一例患者由于排异死亡后,直到1980年才逐渐有了发展,目前已是大医学中心常规手术。此外,简单介绍了心脏移植手术的适应证和禁忌证,最常见的手术病种是扩张性心脏病、冠心病、先天性心脏病。心脏移植术后必须解决的问题是排异反应,本文就排异反应的种类和免疫抑制剂预防和治疗做了一般性介绍,如环孢素A、硫唑嘌吟、强的松的临床应用,也对大量免疫抑制后感染并发症及目前心脏移植概况作了讨论。
We simply recommend historical backgroundabout heart transplantation for treatment of obstinate heartfailure. In 1960s, the first heart transplantation was per-formed in South Africa, but the patient died of organ rejec-tion. Heart transplantion rapidly deveolped only since 1980,but presently it has became a routine operation in many largemedical centers. Dilated cardiomyopathy, coronaryatherosclerotic heart disease and congenital cardiovasculardisease are very common diseases in heart transplantation.After heart transplantation, rejection must be solved. Wepresent rejection types, protection and clinical treatment ofimmune inhibitors such as cyclosporin and predison et al,postoperation infection and general situation recently aboutheart transplantation.
关键词
心脏移植
顽固性
心力衰竭
heart transplantation
treatment of obstinate heart failure
general situation of treatment
