摘要
目的探讨血管内皮生长因子(VEGF)、内皮抑素(ENS)及微血管密度(MVD)在子宫腺肌病(AM)中的表达及意义。方法采用SP免疫组织化学方法检测51例AM患者在位及异位子宫内膜和40例正常子宫内膜组织中VEGF、ENS的表达及MVD值。结果VEGF、ENS、VEGF/ENS、MVD在AM异位内膜中的表达均明显高于正常内膜及在位内膜(P<0.05);VEGF、ENS、VEGF/ENS、MVD在对照组中的表达均为分泌期高于增殖期(P<0.05),在位内膜中VEGF、VEGF/ENS、MVD的表达仍为分泌期高于增殖期(P<0.05),但ENS在增殖期与分泌期的表达差异无统计学意义,失去周期性(P>0.05),异位内膜VEGF、ENS、VEGF/ENS、MVD在增殖期与分泌期的表达差异均无统计学意义,均失去周期性变化(P>0.05);VEGF、VEGF/ENS与MVD分别呈正相关(r=0.36、r=0.43,P<0.05),ENS与MVD的表述呈负相关(r=-0.22,P<0.05)。结论VEGF、MVD、ENS在子宫腺肌病异位、在位内膜中呈高表达,提示局部血供丰富和新生血管形成可能与子宫腺肌病的发病有关。
Objective To detect the expression of vascular endothelial growth factor （VEGF）, endostatin （ENS） and rnicrovessel density （MVD） in eutopic and ectopic endometrium in adenomyosis （AM） and their rela- tionship with clinical significance. Methods Immunohistochemical staining was used to determine the expression of VEGF, ENS and MVD in eutopic and ectopic endometrium tissue specimens obtained from 51 patients with adeno- mysis who underwent hysterectomy and 4：0 normal endometrium tissue samples as control group. Results Expres- sion of VEGF, ENS and MVD in ectopic endometriurn tissue was significantly higher than that in eutopic endometrium and normal endometrium （P〈0.05）. In normal endometrium, expression of VEGF, ENS, MVD in secretory phase were significantly higher than that in proliferative phase （P〈0.05）. However, no significant difference be- tween proliferative phase and secretory phase was found in ectopic endometrium in adenomyosis （P〉0. 05）. The ex- pression of VEGF and VEGF/ENS was correlated with MVD positively （r=0. 36, r=0. 43, P〈0. 05）, while the ex- pression of ENS was correlated with MVD negatively （ r = -- 0. 22, P〈 0. 05）. Condusions The high expression of VEGF, MVD and VEGF/ENS in AM patients indicates that angiogenesis may related to the pathogenesis of adenomyosis. words]
出处
《中国妇产科临床杂志》
2009年第5期363-366,共4页
Chinese Journal of Clinical Obstetrics and Gynecology
基金
广东省科技计划项目(2006B35930003)资助
