摘要
目的探讨肺硬化性血管瘤（sclerosing hemangioma of the lung，SHL）的临床病理特征。方法对21例SHL进行HE染色及免疫组织化学染色，光镜观察。结果本组男4例，女17例，年龄19～65岁，平均42．8岁。HE染色示：SHL主要由实性片块区、乳头状区、血管瘤样区和硬化区4种组织结构组成，瘤细胞有2种即被覆乳头表面、实性区裂隙及血管样腔面的立方细胞和实性区及乳头轴心大小形态一致的多角形细胞；免疫组化染色示：2种细胞均表达EMA和TTF-1，立方细胞表达CK；而多角形细胞弥漫表达vimentin、ER、PR，部分表达Syn、CgA和NSE。结论SHL多见于中青年女性，发病率低，易误诊为肺癌。典型的组织形态特征结合TTF-1、EMA、CK、vimentin等免疫组化染色，是诊断和鉴别诊断SHL的主要方法；ER、PR的高表达可能与女性的高发病率密切相关。
Purpose To describe the clinicopathologic features of sclerosing hemangioma of the lung （SHL）. Methods 21 cases of SHL were studied by HE stain and immunohistochemical stains and light microscopy. Results There were 4 males and 17 females in this group and aged from 19 to 65 years with the average of 42. 8. HE staining revealed that SHL showed a mixture of the following four histological patterns： solid,papillary,hemangioma-like and sclerotic. There were two types of tumor cells： cuboidal cells covered the papillary surface, and lined fissure-cavity in the solid and vascular areas, and polygonal cells with consistent size and morphology in the solid areas and papillary axis. Immunohistochemical staining revealed that the surface of the cuboidal cells expressed TTF-1, CK, and EMA, and the polygonal cells expressed TTF-1, vimentin, ER, PR, NSE, and CgA. Conclusions SHL is particularly prevalent in young and middle-aged women, The incidence rate is low and often misdiagnosed as lung cancer. Morphological analyses and immunohistochemical stains are the main approaches for the diagnosis and differential diagnosis. Expression of ER and PR correlates with predisposition of this tumor to women.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2009年第4期379-381,386,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
肺肿瘤
硬化性血管瘤
临床病理学
免疫组织化学
lung neoplasms
sclerosing hemangioma
clinical pathology
immunohistochemistry
