摘要
通常认为特发性肺纤维化（TPF）为慢性进行性病程。近年来发现在没有明确诱因的情况下部分IPF患者在自然病程中可以出现急性恶化，称为IPF急性加重。其病死率很高，且临床并非少见。目前治疗IPF急性加重多采用大剂量糖皮质激素冲击治疗及强化氧疗。一些研究证实环孢素A、吡非尼酮、抗凝治疗在防治IPF急性加重方面可能有效。
Idiopathic pulmonary fibrosis（IPF） has been described as a chronic progressive disease. Recent evidences have suggested that some patients may experience acute deterioration in the course of disease,which is termed acute exacerbation of IPF. Acute exacerbation of IPF is increasingly recognized as high fatality and common clinical event. Stoss therapy of large dose glucocorticosteroid and strengthening oxygen therapy are adopted in the treatment of the disease. A few studies have shown beneficial effects of cyclosporin A, pirfenidone and anticoagulant therapy in the management and prevention of acute exacerbation of IPF.
出处
《国际呼吸杂志》
2009年第18期1132-1136,共5页
International Journal of Respiration
关键词
特发性肺纤维化
急性加重
诊断
治疗
Idiopathic pulmonary fibrosis
Acute exacerbation
Diagnosis
Treatment
