摘要
链脲佐菌素(STZ)是一种制造糖尿病模型的工具药。从40多年前发现它有致糖尿病作用以来,STZ诱导糖尿病的机制仍未明了。本文将从多种方面阐述其STZ的可能机制及其影响因素,进一步理解化学诱导糖尿病模型,并对糖尿病的发病机制给与启示。
Streptozocin（STZ） is an exclusively drug in initiating diabetic animal model. Although its diabetogenie action found in forty years ago, little is known about its specific diabetogenesis. This review summarized the possible mechanism and interfering factors from many aspects. More enlightenment and further insight into chemical-induced animal model will contribute to understanding on diabetogenesis.
出处
《国际内科学杂志》
CAS
2009年第9期540-543,共4页
International Journal of Internal Medicine
基金
国家973课题(2型糖尿病发病机制和营养干预的代谢组学研究
2006CB503902)
