摘要
体外细胞共培养(cell co-culture)技术能模拟体内生成的微环境,便于更好地观察细胞与细胞、细胞与培养环境之间的相互作用以及探讨药物的作用机制和可能作用的靶点,填补了单层细胞培养和整体动物实验的鸿沟。本文重点阐述了该技术在医学领域的发展和广泛运用,介绍了细胞共培养的应用研究进展。
The cell co-culture in vitro can simulate micro-environment in vivo and bridge the gap between monolayer cell culture and animal experiment. Thus, in many cases the experimental method is valuable in observing the interaction of cells and mechanisms and targets of drugs. This article reviews the cell co-culture and advances in application. The cell coculture can serve as a powerful tool for studying cell interaction and mechanisms of drugs.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2009年第7期827-832,共6页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
国家自然科学基金资助项目(30572356)
高等学校博士学科点专项科研基金(20060366003)
安徽省研究实验基地优秀中青年科研带头人基金(200622805)
安徽医科大学青年科研基金项目(2008kj13)
