摘要
目的探讨高血压病不同中医证型与颈动脉内中膜厚度、血管内皮依赖性舒张功能的相关性,为高血压病中医辨证客观化的研究提供依据。方法采用彩色多普勒超声测量60例高血压病患者及30名健康对照组的颈动脉内-中膜厚度(CIMT)及肱动脉内皮依赖性舒张功能(FMD),并对超声检测所获得的资料进行统计分析。结果高血压各证型组FMD均低于健康对照组,CIMT均高于健康对照组,差异均有统计学意义(P<0.01)。肝火亢盛组(8例)、阴虚阳亢组(28例)FMD均高于阴阳两虚组(10例)及痰湿壅盛组(14例),差异有统计学意义(P<0.01,P<0.05)。肝火亢盛组CIMT均低于其余3个证型组,阴虚阳亢组CIMT低于阴阳两虚组,差异均有统计学意义(P<0.01)。结论CIMT、FMD可作为高血压病中医辨证分型的参考指标。
Objective To explore the relationship of Chinese medicine（CM） syndrome with carotid intima-media thickness（CIMT） and endothelium-dependent vasodilatation function（EDVF） in patients with hypertensive disease（HD） for providing an objective basis of syndrome differentiation in HD patients.Methods Color Doppler′s ultrasound was used to measure the endothelium-dependent flow-mediated dilation（FMD） of brachial artery and carotid intima-media thickness（CIMT） in 60 HD patients（the HD group） and 30 normal controls（the control group）.And the relationship of the outcomes with Chinese medicine syndrome types in patients was analyzed statistically.Results FMD was lower and CIMT was higher in HD patients of all syndrome types than those in the control group respectively（P〈0.01）.Comparison between patients of different syndrome types showed that FMD was higher in patients of Gan-fire exuberance type and yin-deficiency and yang-hyperaction type than in those of both yin-yang deficiency type and phlegm-dampness stagnancy type（P〈0.01,P〈0.05）,while CIMT in patients of Gan-fire exuberance type was the lowest in all types,and that in yin-deficiency and yang-hyperaction type was lower than in yin-yang deficiency type（P〈0.01）.Conclusion CIMT and FMD may be used as a reference index for CM syndrome differentiation in HD patients.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2009年第9期833-835,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
广西卫生厅基金资助项目(No.Z2006092)
关键词
高血压病
中医辨证分型
血管内皮依赖性舒张功能
颈动脉内中膜厚度
超声
hypertensive disease
Chinese medicine syndrome typing
endothelium-dependent vasodilatation function
carotid intima-media thickness
ultrasonography
