摘要
目的:探讨用别嘌呤醇降低血清尿酸水平以延缓慢性肾功能衰竭病程进展。方法:将57例慢性肾功能衰竭并发高尿酸血症患者随机分为治疗组与对照组,治疗组在和对照组相同的慢性肾功不全治疗的基础上,给予别嘌呤醇100～200mg/d。结果:治疗组血清尿酸水平、肌酐及尿素氮水平、血压较对照组低,肾功能恶化者较对照组明显减少(P<0.05)。结论:别嘌呤醇降尿酸水平治疗对延缓肾功能恶化有作用且安全。
Objective： To discuss the use of allopurinol for the reduction of serum uric acid level in patients with chronic renal failuir complicating hyperuricacidemia. Methods：A total of 57 patients with chronic kidney disease complicating hyperuricacidemia were randomly divided into treatment group and control group： the treatment group was given allopurinol 100- 200mg/d in addition to the chronic renal failuir therapy as adopted in the control group . Results： Compared with the control group, serum uric acid , serum bun,serum creatinine level and blood pressure were lower and the rate of renal function deterioration was significantly decreased in the treatment group（P〈0. 05）. Conclusion： Allopurinol is a safe and effective therapy for the protection of renal function.
出处
《陕西医学杂志》
CAS
2009年第9期1191-1192,1212,共3页
Shaanxi Medical Journal
