摘要
目的探讨解脲脲支原体(Uu)及人支原体(Mh)在非淋菌性尿道炎的感染状况,分析近3年支原体的感染及耐药变迁。方法对2005-2007年就诊的泌尿生殖道感染患者进行支原体培养及药敏检测,并对抗菌药物的耐药性变迁进行分析。结果2005-2007年支原体阳性率分别为41.3%、44.0%、44.5%,其中绝大多数是Uu,其次是Uu+Mh、Mh;3年中均以宫颈分泌物的支原体阳性率最高,男性尿道分泌物、前列腺液次之,3年来支原体阳性患者好发年龄以21～30岁年龄段最多,其次为31～40岁年龄段;3年中Uu均对环丙沙星耐药性最高,对交沙霉素、米诺环素、多西环素、甲砜霉素较敏感,Uu+Mh均对交沙霉素、米诺环素、多西环素较敏感;耐药性变迁分析中,除Uu对环丙沙星、Uu+Mh对米诺环素、多西环素、交沙霉素、克拉霉素变化不大外(P>0.05),对另外的抗菌药物均发生明显改变。结论米诺环素、多西环素、交沙霉素为该地区治疗支原体感染的首选药物,支原体的耐药率随着时间的变化而变化,泌尿生殖道支原体的耐药性监测对指导临床治疗具有重要意义。
OBJECTIVE To approach and analyze Ureaplasma urealytium （Uu） and Mycoplasrna horninis （Mh） infection in nongonococcal urethritis （NGU）, and the drug fast diversity in three years. METHODS Mycoplasma of Patients in 20135, 2006 and 2007 infected in Genitourinary tract were cultivanted and detected at drug sensitive experiment. RESULTS Mycoplasma Dositive rate from 2005 to 2007 respectively was 41.3 %, 44.0 % and 44.5%, mycoplasma infection mostly was due to Uu, next was from prostatic Uu＋Mh and Mh. Mycoplasma positive rate of cervical secretions was the highest. In three years male urethral secretions is higher, patients whose mycoplasma is masculine mostly is from 21 yeas old to 30, next from 31 yeas old to 41. Drug resistance of Uu to ciprofloxacin is the highest,but it is sensitive to josamycin, minocycline, deoxycycline, descocin in three years. Uu ＋Mh is sensitive to josamycin, minocycline, deoxycycline. In drug tolerance diversify, they obviously change to another antibiotics, except that Uu is no change to ciprofloxacin, deoxycycline, josamycin, Clarithromycin（P〉0.05）. CONCLUSIONS Minocycline, deoxycycline and josamycin can be chosed to cure Mycoplasma infection in this territory. Drug fast rate of mycoplasma is changing with the time. It is important for guiding clinic to monitor drug resistance of mycoplasma of Genitourinary tract.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2009年第18期2513-2515,共3页
Chinese Journal of Nosocomiology
关键词
非淋菌性尿道炎
支原体
耐药性
变迁
Nongonococcal urethritis
Mycoplasma
Drug resistance
Diversity
