摘要
目的 :观察麝香保心丸能否减少高脂血症对动脉壁的损害作用。方法 :喂饲胆固醇饲料 8周形成实验性高胆固醇血症 ,部分动物于第 7周开始加用麝香保心丸喂养 2周 ;在不同的时间测量动物血脂浓度、心电图改变、血清超氧化物歧化酶 (SOD)水平、动脉壁的光镜及电镜改变 ,以说明麝香保心丸对动脉血管壁的保护作用。结果 :麝香保心丸能显著抑制血清总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL -C)水平的上升 ;增加血清SOD的浓度 ,减轻高脂血症对动脉壁的损害 ,降低动脉内膜的增生。结论 :麝香保心丸对实验性动脉粥样硬化的形成有抑制作用。
Objective: To study the protecting effect of Shexiang Baoxin Pill (SXBXP) on arterial wall in hyperlipemia rabbit model. Methods: Thirty six male, New Zealand rabbits were randomized into three groups: control group, fed with common diet for 8 weeks: Hypercholesterolemia group (HC) and SXBXP group (SX), fed with 1% cholesterol and 3% lard diet for 8 weeks. In SX group, SXBXP was iven from 7th week for 2 weeks. The plasma levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were measured at the first, 6th and the 8th week of experiment. Serum superoxide dismutase (SOD) and electrocardiography (ECG) were also evaluated at the 8th week. Light microscopy and transmission electron microscopy were adopted to assess the degree of pathologic damage of arterial wall. Results: SXBXP could reduce the levels of serum TC and LDL-C, as compared with the HC group, P<0 05. It could also reduce the extent of atherosclerotic lesion and the severity of intimal proliferation. Conclusion: SXBXP has the effect of inhibiting developement of experimental atherosclerosis.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1998年第8期486-489,共4页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
麝香保心丸
高脂血症
动脉壁
动脉粥样硬化
Shexiang Baoxin Pill, hypercholesterolemia, atherosclerosis, superoxide dismutase
