摘要
目的:探讨双源CT最大斜率法、Patlak肿瘤灌注成像诊断胃癌的应用价值。材料和方法:对经胃镜活检证实的胃腺癌患者行双源CT灌注扫描,获得灌注参数,比较胃癌和正常胃壁灌注参数的差异,评估胃癌组织的血流动力学变化,再分别根据肿瘤细胞分化程度、胃壁浸润深度和有无淋巴结转移分成若干组,比较各组患者灌注参数的差异,探索其在评估胃癌生物学行为中的作用。结果:MIP、AP、BV、BF、PC、CT增强值诸参数胃癌组织均高于正常胃壁组织(P<0.05)。不同细胞分化程度、胃壁浸润不同深度、有无淋巴结转移各组之间未见显著性差异,AP值与胃壁浸润深度呈正相关。结论:双源CT灌注成像能反应胃癌的血流动力学变化,对胃癌的诊断及鉴别诊断有意义,对胃癌的生物学行为评估作用尚有限,AP值在一定程度上能反映胃癌的胃壁浸润深度。
Purpose： To discuss the clinical application and the role using the dual source CT maximum slope method and intratumoral perfusion imaging in the diagnosis of gastric cancer. Materials and Methods： The patients with gastric cancer who were confirmed by endoscopic biopsy underwent dural source perfusion CT scan. Then the perfusion parameters of the patients were compared with that of the volunteers. After that, the hemodynamics of gastric cancer tissue were assessed. Several groups were divided according to the differentiation degree of tumor cells, the invasive depth in the gastric wall and the metastasis of the lymph node, and finally the significance of the perfusion parameters and the value of the biological behaviors of gastric cancer in different groups of patients were investigated. Results ： The parameters including MIP, AP,BV,BF,PPC ,CT enhancement value in the tissue of gastric cancer were higher than in the normal gastric wall and they had significant differences（P 〈 0.05）. Obvious differences were not observed in different cell differentiation degrees, the various invasive depths in the gastric wall and the metastasis of the lymph node, but the value of AP had the positive relation with the invasive depth in the gastric wall. Conclusions： Dual Source CT perfusion imaging could reflect the hemodynamic changes of gastric cancer and could play an important role in the diagnosis and differential diagnosis of gastric cancer. Although it has the limitation in evaluating the biological behaviors of gastric cancer,the value of AP could have the reflection of invasive depths in the gastric wall to some extent.
出处
《中国医学影像学杂志》
CSCD
北大核心
2009年第5期329-332,共4页
Chinese Journal of Medical Imaging
关键词
双源CT
灌注成像
胃肿瘤
dual source CT
perfusion imaging
stomach neoplasms
