摘要
目的探讨高血压患者循环一氧化氮／内皮素（ＮＯ／ＥＴ）平衡的变化及与血压的关系。方法高血压组３０例，对照组２５例，以Ｇｒｉｅｓｓ法测循环ＮＯ水平，放免法测血浆内皮素（ＥＴ）水平，变量间的比较按需要行团体、配对ｔ检验，直线相关分析，逐步回归分析。结果高血压组循环ＮＯ水平明显低于对照组（Ｐ＜０．０１），血浆ＥＴ则明显增高（Ｐ＜０．０１），ＮＯ／ＥＴ比值较对照组明显下降（Ｐ＜０．０１）。两组均发现平均血压与ＮＯ／ＥＴ比值呈显著负相关（对照组ｒ＝－０．５８１，Ｐ＜０．０１，高血压组ｒ＝－０．３５，Ｐ＜０．０５）。结论高血压患者循环ＮＯ／ＥＴ失衡，与高血压的维持与发展有关。
Objective\ To study the balance of NO/ET in blood of patients with essential hypertension(EH).\ Methods\ The concentrations of serum NO 2(a stable oxidation products of NO) were measured by spectrophotometry,and the levels of plasma endothelin(ET) were measured by radioimmunoassay in all subjects.\ Results\ The ratio of NO/ET was significantly lower in EH group than in control group(P<0.01).\ The ration of NO/ET was inversely related to MBP in two groups (control∶r=-0.581 P<0.01;EH:r=-0.35 P<0.05).\ Conclusion\ Imbalance of NO/ET is present in blood of patients with EH,which may play an important role in sustaining and developing hypertension
出处
《福建医科大学学报》
1998年第1期58-61,共4页
Journal of Fujian Medical University
基金
福建省自然科学基金
关键词
高血压
一氧化氮
内皮素
测定
essential hypertension\ \ nitric oxide\ \ endothelin
