摘要
目的优选卡马西平固体脂质纳米粒(SLN)的处方及制备工艺。方法采用正交实验法对卡马西平-单硬脂酸甘油酯用量比(A)、泊洛沙姆用量(B)、吐温80用量(C)、超声时间(D)等4个因素选取3个水平,考察卡马西平固体脂质纳米粒包封率,用直观法和方差分析法分析结果。结果影响因素为:卡马西平-单硬脂酸甘油酯用量比>吐温80用量>泊洛沙姆用量>超声时间。结论卡马西平SLN最佳制备工艺为:A3B1C1D1,即卡马西平-单硬脂酸甘油酯质量比为10:100,泊洛沙姆用量为100 mg,超声时间为5 min,不用吐温80。
Objective To determine the optimum formulation and preparation procedure of cambamazepine SLN, Methods Three levels in each of four factors （ the ratio of earhamazepine and glycerol monostearate, quantity of poloxamer and tween-80, time of ultrasonic processing） were selected with orthogonal design. The encapsulation efficiency of cambamazepine SLN was tested. The results were analyzed by means of direct-viewing and ANOVA . Results The important four factors were ranked as follow ： the ratio of carbamazepine and glycerol monostearate 〉 quantity of tween-80 〉 quantity of poloxamer 〉 time of the ultrasonic processing. Conclusion The optimum formulation and preparation procedure of cambamazepine SLN were that ： using 10 ： 100 of carbamazepine and glycerol monostearate, consuming 100 mg poloxamer and 0 mg tween-80, and taking 5 min of ultrasonic processing.
出处
《医药导报》
CAS
2009年第9期1192-1194,共3页
Herald of Medicine
基金
陕西省科技攻关项目[基金编号:2004K10-G4(3)]
关键词
卡马西平
纳米粒
制备工艺
正交实验
Cambamazepine
SLN
Preparation procedure
Orthogonal design methods
