摘要
目的:探讨淋巴结微转移对结直肠癌患者病理分期的影响。方法:对2003年3月至2008年10月间手术切除的60例结直肠癌患者的990枚淋巴结进行常规HE染色和CK20免疫组化检查,检测结直肠癌的淋巴结转移,并对结果进行统计学分析。结果:应用HE染色法淋巴结转移检出率27.2%(269/990),CK20免疫组化淋巴转移检测率为37.2%(368/990),两者差异有统计学意义(P〈0.05)。99枚淋巴结检出有微转移,11例TNM分期提高,HE染色重新分期率为18.3%(11/60)。结论:CK20免疫组化的检测可以显著提高淋巴结转移的检出率,有助于更准确地进行结直肠癌的临床病理分期。
Objective: To detect micrometastasis in regional lymph nodes and evaluate the significance of the new assessment of nodal status in determining pN staging of colorectal carcinoma. Methods: In addition to HE, IHC with Cytokeratin-20 was used to detect icrometastasis in 990 lymph nodes from 60 patients with colorectal carcinoma from Mar. 2003 to Oct. 2008. Results: The detection rate of HE staining was 27.2% (269/990), and the detection rate of IHC staining was 37.2% (368/990) ( P 〈 0.05 ). Lymph node micrometastasis was further detected in 99 nodes from 11 patients. The rate of second HE staging was 18. 3 % (11/60). Conclusion: IHC with Cytokeratin-20 can increase the detecting of lymph node metastasis and have a significant impact on the staging system of colorectal carcinoma.
出处
《肿瘤预防与治疗》
2009年第2期165-167,共3页
Journal of Cancer Control And Treatment
基金
重庆市卫生局科研项目资助(编号:06-2-011)
关键词
结直肠癌
淋巴结微转移
免疫组化
临床分期
Colorectal Carcinoma
Lymph Node Micrometastasis
IHC
Clinical Staging