摘要
目的：探讨卵巢透明细胞癌（OCCC）的临床特点和预后。方法：回顾性分析天津医科大学附属肿瘤医院1995年至2005年收治的46例卵巢透明细胞癌,对其临床症状、合并子宫内膜异位症、血CA125水平、5年生存率,对化疗的反应、预后等做分析,并与同期43例卵巢浆液性腺癌（0SCC）进行比较。结果：早期卵巢透明细胞癌患者占73.91%,明显多于浆液性乳头状囊腺癌（30.23%）,（P=0.000）;I期~II期5年生存率（36.84%）明显低于浆液性腺癌（73.33%）,而复发率（40.9%）高于浆液性腺癌（21.43%）,差异有统计学意义（P=0.002）。透明细胞癌紫杉醇联合铂类/传统铂类为主的化疗治疗有效率分别为33.33%/26.32%,差异无统计学意义（P=0.10）。与浆液性腺癌相比较,透明细胞癌常合并卵巢子宫内膜异位症（22.64%）;传统意义上的满意减瘤术预后差,5年生存率分别为52.94%/36.36%,差异具有统计学意义（P=0.02）。结论：卵巢透明细胞癌以早期患者多见,易复发,对化疗不敏感,预后差;紫杉醇联合铂类化疗有效率与传统铂类化疗相比较无差异;最大限度地切除肿瘤可能会改善其预后。
Objective： To study the clinical characteristics and the prognosis of ovarian clear cell carcinoma（OCCC）. Methods： Forty-six patients with the clear cell carcinoma of ovary and 43 patientswith the serous adenocarcinoma of ovary admitted in Tian- Jin Ontology Hospital from 1995 to 2005 were analyzed retrospectively. The clinical symptoms, endometriosis, serum CA125 level, 5- year survival rates, chemotherapy effective rates and prognosis were compared. Results： The percentages of I-II stage patients in the clear cell carcinoma of ovary and the serous adenocarcinoma of ovary were 73.91% and 30.23% respectively, the difference was significant （P 〈0. 001 ）, and the 5-year survival rates were 36.84% and 73.33% respectively;the recurrent rates were 40.9% and 21. 43% respectively （P 〈 0.05 ）, and OCCC were often combined with endometriosis（22.64% ）. The conventional satisfactory eytoreduetire surgery could not improve their prognosis. Compared to OSCC, the 5-year survival rate of OCCC was only 36, 36% and had significant difference （P = 0.02）. The patients undertaken Paclitaxel-platinum-based chemotherapy had higher effective rate （33.33%） than that undertaken conventional platinum-based chemotherapy （26.32%） （P = 0.10）. Conclusion： The early stage patients with the clear cell carcinoma of the ovary are easier to get recurrence, and have significantly lower response rate to chemotherapy. The chemotherapy effective rate has no significant difference between paclitaxel-platinum-based chemotherapy and conventional platinum-based chemotherapy. The maximally dissection of the tumor may improve the prognosis of OCCC.
出处
《肿瘤预防与治疗》
2009年第2期145-148,共4页
Journal of Cancer Control And Treatment
关键词
卵巢肿瘤
透明细胞癌
浆液性囊腺癌
复发率
化疗有效率
CA125
Ovarian Neoplasms
Clear Cell Carcinoma
Adenocarcinoma
Recurrent Rate
Chemotherapy Effective Rate
CA125
