摘要
目的：观察重组人血小板生成素（rhTPO）治疗妇科恶性肿瘤化疗相关性血小板减少症的疗效及副作用。方法：回顾性分析北京大学人民医院妇产科2007年10月~2008年10月,妇科恶性肿瘤化疗期间血小板减少患者的临床资料,其中20例使用rhTPO者为用药组,未使用rhTPO 10例为对照组。结果：20例使用rhTPO治疗后,平均10.5±4.9天血小板升高,并恢复正常,而对照组则于21.4±8.6天血小板恢复正常（P〈0.001）。使用rhTPO患者中4例患者产生副作用,分别为头晕1例次,发热2例次,恶心呕吐1例次。结论：重组人血小板生成素（rhT-PO）可治疗化疗导致的血小板减少,且不良反应轻微,但尚需扩大样本进一步研究。
Objective： To investigate the efficacy and safety of recombinant human thrombopoietin（rhTPO） to treat thrombocytopenia caused by chemotherapy（CIT） in patients with gynecological tumor. Methods ： The clinical data of the cases of gynecological malignant tumor hospitalized in Peking university People＇ s Hospial from Oct. 2007 to Oct. 2008 were retrospectively analyzed. 20 cases of CIT treated by rhTPO were regarded as trial group, while 10 cases without using rhTPO as control group. The number of platelet and the time of recovery between the two groups were compared by SPSS. Results： The number of platelet of trial group increased 10. 5±4.9 days after treated by rhTPO, and the side-effccts were vertigo in one case, fever in two cases and nausea and vomiting in one case, but the number of platelet of the control group recovered to normal in 21.4 ± 8.6 days. Conclusion： rhTPO can promote the recovery of thrombocytopenia caused by chemotherapy and has slight adverse effect for patients with gynecological oncology, which needs be further confirmed by multiple center study.
出处
《肿瘤预防与治疗》
2009年第2期142-144,148,共4页
Journal of Cancer Control And Treatment
关键词
重组人血小板生成素
血小板减少症
化学治疗
肿瘤
Recombinant Human Thrombopoietin
Thrombocytopenia
Chemotherapy
Gynecological Tumor
