摘要
Aplastic anemia （AA）, myelodysplastic syndrome （MDS）, and paroxysmal noctumal hemoglobinuria （PNH） are bone marrow failure disorders closely related to each other. PNH often occurs in the course of AA or MDS-refractory anemia （RA）. Acquired AA patients, particularly with PNH clones, have benefited from the immunosuppressive therapy （IST）. Although the possible immune abnormality was not considered as the core mechanism in MDS pathology,1 MDS-RA cases with PNH clones also reflected a high probability of response to IST. We report here one rare case of advanced MDS with PNH clones diagnosed by flow cytometry （FCM）.
Aplastic anemia （AA）, myelodysplastic syndrome （MDS）, and paroxysmal noctumal hemoglobinuria （PNH） are bone marrow failure disorders closely related to each other. PNH often occurs in the course of AA or MDS-refractory anemia （RA）. Acquired AA patients, particularly with PNH clones, have benefited from the immunosuppressive therapy （IST）. Although the possible immune abnormality was not considered as the core mechanism in MDS pathology,1 MDS-RA cases with PNH clones also reflected a high probability of response to IST. We report here one rare case of advanced MDS with PNH clones diagnosed by flow cytometry （FCM）.
