摘要
目的:研究有氧运动(游泳)对大鼠血糖、血脂和血液凝固功能的影响。方法:30只SD大鼠进行不同强度的游泳训练后,测定其血糖、血脂、血浆组织因子(TF)活性、组织因子途径抑制物(TFPI)抗原、组织型纤溶酶原激活物(t-PA)和纤溶酶原激活剂抑制物-1(PAI-1)的活性。结果:1)与对照组相比,运动对大鼠血糖有降低趋势,但差异无统计学意义(p>0.05);2)小强度运动使大鼠血清LDL明显降低(p<0.05),大强度运动具有升高血清LDL的趋势;3)小运动组大鼠血清HDL浓度呈逐渐升高趋势,而大强度组的大鼠血清HDL明显降低(p<0.05);4)小强度游泳运动后,血浆t-PA活性及t-PA/PAI-1比值明显升高(p<0.01),PAI-1活性却明显降低(p<0.05);大强度游泳运动组t-PA活性没有明显改变,PAI-1活性有所升高;5)与对照组相比,运动训练使TFPI水平升高,其中小强度组TFPI含量(p<0.05)和TFPI/TF比值显著性升高(p<0.01),大强度组的TF含量有所升高,而TFPI/TF比值变化不明显(p>0.05)。结论:小强度的运动训练可以改善机体的凝血和纤溶功能,而大强度的训练不利于改善纤溶功能;且降低机体的抗凝功能。
Objective： The aim of this study is to observe the changes of blood glucose, blood lipid and coagulative system of rats after aerobic - exercise （Swimming）. Method： 30 Sprague- Dawley male rats are randomly divided into three groups, taking part in different intensities swimming trainings. The content of blood glucose, blood lipid, the activity of plasma t - PA, PAI- 1, the antigen contents of TF and TFPI are measured. Results： 1） Comparing with the control group, the content of blood glucose shows little decrease in aerobic - exercise group （p 〉 0.05） ; 2） Compared with the control, LDL decreases evidently in low intensity swimming training group（p 〈 0.05） and increases in high intensity swimming training group; 3） HDL increases in low intensity swimming training group, but decreases evidently in high intensity swimming training group; 4） low intensity swimming training may significantly increase t - PA activity and ratio of t - PAL to PAI- 1 （p 〈 0.01）, and reduce PAI- 1 activity（p 〈 0.05）. High intensity swimming training increases PAI- 1 activity and does not change t - PA activity. The swimming training may increase the antigen concentration of TFPI, and high intensity swimming training may increase plasm TFPI concentration（p 〈 0.05） and the ratio of TFPI to TF（p 〈 0.01 ）, and high intensity swimming training significantly increases antigen concentration of TF, but does not change the ratio of TFPI to TF. Conclusion： low intensity swimming training may improve the coagulation and fibrinolytic activity, but high intensity swimruing training is not helpful to improve the fibrinolytic activity and reduce the function of anti - coagulation system.
出处
《北京体育大学学报》
CSSCI
北大核心
2009年第7期66-68,共3页
Journal of Beijing Sport University
关键词
运动
大鼠
血糖
血脂
血液凝固
exercise
rat
blood glucose
blood lipid
blood coagulation
