摘要
血管生成拟态(vasculogenic mimicry,VM)是近几年在少数高度恶性肿瘤中发现的一种独立于血管生成的全新肿瘤内微循环模式,即由恶性肿瘤细胞而非血管内皮细胞围成、细胞外基质界限的血管样结构.VM与肿瘤侵袭、转移及患者预后密切相关,其发生和肿瘤细胞呈现多潜能胚胎样表型及多种蛋白分子的生物学效应有关,肿瘤局部微环境也起着重要作用.现就VM的特点、发生机制及临床意义等研究进展作一综述.
Vasculogenic mimicry （VM）, a term that describes a novel form of angiogenesis-independent microcirculation pattern recently found in few highly aggressive tumors, is formed by tumor cells, rather than endothelial cells. VM is closely correlated with the invasiveness, metastasis and prognosis of related tumors. The presence of VM is associated with an embryonic like phenotype acquired by tumor cells and the biological effects of many proteins. Furthermore, tumor microenvironment also plays an important role in the development of VM. Here, we will review the advances in research on the characteristic, formative mechanisms and clinical significance of VM.
出处
《世界华人消化杂志》
CAS
北大核心
2009年第20期2015-2020,共6页
World Chinese Journal of Digestology
关键词
血管生成拟态
血管生成
肿瘤
微循环
Vasculogenic mimicry
Angiogenesis
Tumor
Microcirculation
